This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018].
Description
Bioinformatics
Weight | 1 lbs |
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Size | 20ug Purified Ab with BSA and Azide at 200ug/ml, 100ug, 100ug Purified Ab with BSA and Azide at 200ug/ml |
Application | IHC |
Symbol | VDR |
Isotype | Mouse / IgG1 |
Synonyms | NR1I1, PPP1R163 |
Entrez Gene ID | 7421 |
UniProt | P11473 |
Clone | PCRP-VDR-1F11 |
Supplied As | 200ug/ml of recombinant mAb Purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
Storage and Stability | Antibody with azide – store at 2 to 8°C. Antibody without azide – store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
Categories | Cell Biology, Neurosciences, Transcription Factors |
Additional Information
Storage and Stability |
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
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Supplied As |
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
Limitations |
This antibody is available for research use only and is not approved for use in diagnosis. |
Warranty |
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product. |
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