Datasheet TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
| Weight | 1 lbs |
|---|---|
| Size | 20ug Purified Ab with BSA and Azide at 200ug/ml, 100ug Purified Ab with BSA and Azide at 200ug/ml, 100ug Purified Ab WITHOUT BSA and Azide at 1.0mg/ml |
| Application | IHC |
| Symbol | HAVCR2 |
| Isotype | kappa, Mouse / IgG2a |
| Species Reactivity | Human. |
| Synonyms | CD366, HAVcr-2, KIM-3, SPTCL, TIM3, TIMD-3, TIMD3, Tim-3 |
| Positive Control | BT474, HDLM-2 or Daudi cells. Tonsil, HepG2, lymph node or spleen., PC3 |
| Cellular Localization | Cell surface |
| Mol. Weight of Antigen | 60kDa |
| Entrez Gene ID | 84868 |
| UniProt | Q8TDQ0 |
| Clone | TIM3/3113 |
| Supplied As | 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage and Stability | Antibody with azide – store at 2 to 8°C. Antibody without azide – store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| Categories | Cancer, Cell Biology, Myeloid Immunity, Neurosciences |
Related products
Antibodies
Antibodies
Antibodies
Antibodies
Antibodies
Antibodies
