Datasheet Focal adhesions are identified as areas within the plasma membrane of tissue culture cells that adhere tightly to the underlying substrate. In vivo, these regions are involved in the adhesion of cells to the extracellular matrix. Paxillin and vinculin are cytoskeletal, focal adhesion proteins that are components of a protein complex which links the Actin network to the plasma membrane. Vinculin binding sites have been identified on other cytoskeletal proteins, including Talin and -Actinin each contain Actin binding sites. Reportedly, vinculin is a potential plasma biomarker for Age-related Macular Degeneration (AMD). The early detection of AMD using novel plasma biomarkers with genetic modeling may enable timely treatment and vision preservation in the elderly.
| Weight | 1 lbs |
|---|---|
| Size | 20ug Purified Ab with BSA and Azide at 200ug/ml, 100ug Purified Ab with BSA and Azide at 200ug/ml, 100ug Purified Ab WITHOUT BSA and Azide at 1.0mg/ml |
| Application | IHC |
| Symbol | VCL |
| Isotype | kappa, Mouse / IgG1 |
| Species Reactivity | Human. Mouse. |
| Synonyms | CMD1W, CMH15, HEL114, MV, MVCL |
| Positive Control | Human Bladder and Testis. |
| Cellular Localization | Cytoplasmic |
| Mol. Weight of Antigen | 117kDa |
| Entrez Gene ID | 7414 |
| UniProt | P18206 |
| Clone | VCL/2573 |
| Supplied As | 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage and Stability | Antibody with azide – store at 2 to 8°C. Antibody without azide – store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| Categories | Cell Biology, Neurosciences |
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